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Tanshinone IIA Suppresses Non-Small Cell Lung Cancer Through Beclin-1-Mediated Autophagic Apoptosis Article

Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang

Engineering 2022, Volume 19, Issue 12,   Pages 128-138 doi: 10.1016/j.eng.2021.07.014

Abstract: Tanshinone IIA (Tan IIA), an active ingredient of a commonly used traditional Chinese herb SalviaIt has been found that Tan IIA could inhibit lung cancer in vitro and in vivo by inducingIn addition, Tan IIA induced more autophagosomes, up-regulated light chain 3β (LC-3B) I and LC-3Bapoptosis that Tan IIA induced was dependent on Beclin-1.Overall, our study demonstrated a new treatment mechanism of Tan IIA and suggested that Tan IIA is a

Keywords： Tan IIA     Autophagy     Apoptosis     Beclin-1    

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Building information modeling based on intelligent parametric technology

ZENG Xudong, TAN Jie

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 3,   Pages 367-370 doi: 10.1007/s11709-007-0049-4

Abstract: In order to push the information organization process of the building industry, promote sustainable architectural design and enhance the competitiveness of China’s building industry, the author studies building information modeling (BIM) based on intelligent parametric modeling technology. Building information modeling is a new technology in the field of computer aided architectural design, which contains not only geometric data, but also the great amount of engineering data throughout the lifecycle of a building. The author also compares BIM technology with two-dimensional CAD technology, and demonstrates the advantages and characteristics of intelligent parametric modeling technology. Building information modeling, which is based on intelligent parametric modeling technology, will certainly replace traditional computer aided architectural design and become the new driving force to push forward China s building industry in this information age.
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Immunoregulatory effects of

Dan Luo, Zhengyun Zuo, Hongyan Zhao, Yong Tan, Cheng Xiao

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 556-563 doi: 10.1007/s11684-018-0649-5

Abstract: Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of T and B cells; ratio of T cell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

Keywords： Tripterygium wilfordii Hook F     immunoregulation     clinical studies    

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Introduction to the special section on the Symposium on Computational Fluid Dynamics and Molecular Simulation

Tianwei TAN, Peiyong QIN,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 241-241 doi: 10.1007/s11705-009-0285-3

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Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 179-184 doi: 10.15302/J-FASE-2014020

Abstract: Butyrylcholinesterase (BCHE) is a natural bioscavenger that protects humans against organophosphate toxicity. Due to the limited yield of human BCHE (hBCHE) when purifying from human plasma, it is necessary to find an alternative method to produce this protein. One potential method is to produce transgenic livestock that make modified milk containing high concentration of hBCHE. In this study, we cloned the gene into a human lactoferrin (hLF) bacterial artificial chromosome (BAC) construct to make a hLF-hBCHE BAC construct. Subsequently, we injected the BAC construct into pronuclei of mouse fertilized embryos and generated transgenic mice. Expression analysis showed that recombinant hBCHE (rhBCHE) was expressed efficiently in the mammary gland of the transgenic mice and the concentration of rhBCHE in the milk of individual mice ranged from 76±12 to 159±28 mg·L . Protein function tests showed that rhBCHE has the same enzymatic activity as the native hBCHE. Our results pave the way for making transgenic livestock to produce large quantities of rhBCHE.

Keywords： recombinant human butyrylcholinesterase (rhBCHE)     human lactoferrin bacterial artificial chromosome (hLF BAC)     transgenic mice     milk    

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Nanofiltration for separation and purification of saccharides from biomass

Xianhui Li, Sheng Tan, Jianquan Luo, Manuel Pinelo

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 4,   Pages 837-853 doi: 10.1007/s11705-020-2020-z

Abstract: Saccharide production is critical to the development of biotechnology in the field of food and biofuel. The extraction of saccharide from biomass-based hydrolysate mixtures has become a trend due to low cost and abundant biomass reserves. Compared to conventional methods of fractionation and recovery of saccharides, nanofiltration (NF) has received considerable attention in recent decades because of its high selectivity and low energy consumption and environmental impact. In this review the advantages and challenges of NF based technology in the separation of saccharides are critically evaluated. Hybrid membrane processes, i.e., combining NF with ultrafiltration, can complement each other to provide an efficient approach for removal of unwanted solutes to obtain higher purity saccharides. However, use of NF membrane separation technology is limited due to irreversible membrane fouling that results in high capital and operating costs. Future development of NF membrane technology should therefore focus on improving material stability, antifouling ability and saccharide targeting selectivity, as well as on engineering aspects such as process optimisation and membrane module design.

Keywords： saccharides     nanofiltration membrane     hybrid membrane process     biomas    

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Creative design inspired by biological knowledge: Technologies and methods

Runhua TAN, Wei LIU, Guozhong CAO, Yuan SHI

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 1,   Pages 1-14 doi: 10.1007/s11465-018-0511-0

Abstract: Biological knowledge is becoming an important source of inspiration for developing creative solutions to engineering design problems and even has a huge potential in formulating ideas that can help firms compete successfully in a dynamic market. To identify the technologies and methods that can facilitate the development of biologically inspired creative designs, this research briefly reviews the existing biological-knowledge-based theories and methods and examines the application of biological-knowledge-inspired designs in various fields. Afterward, this research thoroughly examines the four dimensions of key technologies that underlie the biologically inspired design (BID) process. This research then discusses the future development trends of the BID process before presenting the conclusions.

Keywords： creative design     biologically inspired methods     key technologies    

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Dilution rate and microstructure of TIG arc Ni-Al powder surfacing layer

SHAN Jiguo, DONG Wei, TAN Wenda, ZHANG Di, REN Jialie

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 1,   Pages 20-24 doi: 10.1007/s11465-007-0003-0

Abstract: Surfacing beads are prepared by a direct current tungsten inert gas arc nickel-aluminum (Ni-Al) powder surfacing process. With the aim of controlling the dilution rate and obtaining surfacing beads rich in intermetallic compounds, the effects of surfacing parameters on geometric parameters, dilution rate, composition, and microstructure of the bead are investigated. An assistant cooler, which can potentially reduce the temperature of the base metal, is used in the surfacing process and its effect on dilution rate and microstructure is studied. The result indicates that with the surfacing parameter combination of low current and speed, the width and penetration of the bead decrease, reinforcement increases, and dilution rate drops markedly. With the reduction of the parameter combination, the intergranular phase ?-(Fe, Ni) is formed in the grain boundaries of Ni-Al intermetallic matrix instead of the intergranular phase ?-Fe, and large amount of intermetallics are obtained. With the use of an assistant cooler on a selected operation condition during the surfacing process, the reinforcement of the bead increases, penetration decreases, and dilution rate declines. The use of an assistant cooler helps obtain a surfacing bead composed of only intermetallics.

Keywords： decrease     Ni-Al     surfacing parameter     temperature     surfacing process    

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Shape design of arch dams under load uncertainties with robust optimization

Fengjie TAN, Tom LAHMER

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4,   Pages 852-862 doi: 10.1007/s11709-019-0522-x

Abstract: Due to an increased need in hydro-electricity, water storage, and flood protection, it is assumed that a series of new dams will be build throughout the world. The focus of this paper is on the non-probabilistic-based design of new arch-type dams by applying means of robust design optimization (RDO). This type of optimization takes into account uncertainties in the loads and in the material properties of the structure. As classical procedures of probabilistic-based optimization under uncertainties, such as RDO and reliability-based design optimization (RBDO), are in general computationally expensive and rely on estimates of the system’s response variance, we will not follow a full-probabilistic approach but work with predefined confidence levels. This leads to a bi-level optimization program where the volume of the dam is optimized under the worst combination of the uncertain parameters. As a result, robust and reliable designs are obtained and the result is independent from any assumptions on stochastic properties of the random variables in the model. The optimization of an arch-type dam is realized here by a robust optimization method under load uncertainty, where hydraulic and thermal loads are considered. The load uncertainty is modeled as an ellipsoidal expression. Comparing with any traditional deterministic optimization method, which only concerns the minimum objective value and offers a solution candidate close to limit-states, the RDO method provides a robust solution against uncertainty. To reduce the computational cost, a ranking strategy and an approximation model are further involved to do a preliminary screening. By this means, the robust design can generate an improved arch dam structure that ensures both safety and serviceability during its lifetime.

Keywords： arch dam     shape optimization     robust optimization     load uncertainty     approximation model    

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Study on the cohesion and adhesion of hot-poured crack sealants

Meng GUO, Yiqiu TAN, Xuesong DU, Zhaofeng LV

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 353-359 doi: 10.1007/s11709-017-0400-3

Abstract: Filling crack sealant is a main method to repair cracking of pavement. The cohesion and adhesion of crack sealant directly determine its service performance and durability. However, the competitive mechanism of cohesion and adhesion failure modes is not clear currently. This research proposed two methods to evaluate cohesion and adhesion of crack sealant, and analyzed the influence of temperature on cohesion and adhesion. The effect of moisture on low-temperature performance of crack sealant was also be evaluated by conducting a soaking test. Results show that with the decrease of temperature, the cohesion force of crack sealant increases significantly, while the adhesion force changes little. There is a critical temperature at which the cohesion force equals the adhesion force. When the temperature is higher, the adhesion force will be greater than cohesion force, and the cohesion failure will happen more easily. In contrast, the adhesion failure will happen more easily when the temperature is lower than the critical value. Soaking in 25 °C water for 24–48 hours will slightly improve the low-temperature tension performance of crack sealant. However, soaking in 60 °C water for 24 hours will decrease the failure energy of low-temperature tension and damage the durability of crack sealant.

Keywords： crack sealant     concrete pavement     cohesion     adhesion     moisture damage    

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Fabrication of titanosilicate pillared MFI zeolites with tailored catalytic activity

Baoyu Liu, Qiaowen Mu, Jiajin Huang, Wei Tan, Jing Xiao

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 772-782 doi: 10.1007/s11705-019-1859-3

Abstract: Titanosilicate pillared MFI zeolite nanosheets were successfully synthesized by infiltrating the mixed tetraethyl orthosilicate (TEOS)/tetrabutyl orthotitanate (TBOT) solvent into the gallery space between adjacent MFI zeolite layers. The obtained zeolite catalysts were characterized using powder X-ray diffraction, N adsorption/desorption isotherms, scanning electron microscopy, transmission electron microscopy, ultraviolet–visible spectroscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy techniques. The H O oxidation of dibenzothiophene (DBT) was used to evaluate the catalytic performance of the obtained titanosilicate pillared MFI zeolites. The conversion of DBT and selectivity of dibenzothiophene sulfone (DBTS) were most affected by the textural properties of the zeolites. This was attributed to the DBT and DBTS molecules being larger than micropores of the MFI zeolites. The conversion of DBT and yield of DBTS could be systematically tailored by tuning the molar ratio of the TEOS/TBOT solvent. These results implied that a balance between the meso- and microporosity of zeolites and tetrahedrally coordinated Ti(IV) active sites of titanosilicate pillars can be achieved for the preparation of desired catalysts during the oxidation of bulk S compounds.

Keywords： MFI zeolite     catalysis     nanosheets     fabrication    

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Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 82-89 doi: 10.1007/s11684-010-0014-9

Abstract: Variation of individuals’ DNA repair capacity has been linked to cancer susceptibility. The xeroderma pigmentsum group F (XPF) plays a pivotal role in nucleotide-excision repair (NER) pathway. This study was to examine the functional significance of promoter polymorphisms and their association with lung cancer risk. The function of promoter polymorphisms was tested by a set of biochemical assays, and their effects on lung cancer risk were determined by a case-control analysis of 988 patients with lung cancer and 986 controls. The −673T allele showed a significantly higher transcriptional activity as compared with the −673C allele. The −673TT genotype was associated with a decreased risk of lung cancer compared with the CC genotype (adjusted OR=0.62, 95% CI=0.42–0.91; =0.015) and this effect was more significant among males (adjusted OR=0.55, 95% CI=0.35–0.86; =0.009), elder subjects (adjusted OR=0.51, 95% CI=0.30–0.86; =0.012), and light smokers (adjusted OR=0.35, 95% CI=0.14–0.88; =0.026). These findings suggest that functional polymorphisms influencing DNA repair capacity may confer susceptibility to lung cancer.

Keywords： XPF     polymorphism     lung cancer    

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A state-of-the-art review on interfacial behavior between asphalt binder and mineral aggregate

Meng GUO, Yiqiu TAN, Linbing WANG, Yue HOU

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 2,   Pages 248-259 doi: 10.1007/s11709-017-0422-x

Abstract: The interface between asphalt binder and mineral aggregate directly affects the service life of pavement because the defects and stress concentration occur more easily there. The interaction between asphalt binder and mineral aggregate is the main cause of forming the interface. This paper presents an extensive review on the test technologies and analysis methods of interfacial interaction, including molecular dynamics simulation, phase field approach, absorption tests, rheological methods and macro mechanical tests. All of the studies conducted on this topic clearly indicated that the interfacial interaction between asphalt binder and mineral aggregate is a physical-chemical process, and can be qualitatively characterized by microscopical technique (such as SEM and AFM), and also can be quantitatively evaluated by rheological methods and interfacial mechanical tests. Molecular dynamics simulation and phase field approach were also demonstrated to be effective methods to study the interfacial behavior and its mechanism.

Keywords： Asphalt binder     Mineral aggregate     Interfacial behavior     Multiscale    

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SiO2 passivation layer grown by liquid phase deposition for silicon solar cell application

Yanlin CHEN,Sihua ZHONG,Miao TAN,Wenzhong SHEN

Frontiers in Energy 2017, Volume 11, Issue 1,   Pages 52-59 doi: 10.1007/s11708-016-0429-3

Abstract: Surface passivation is one of the primary requirements for high efficient silicon solar cells. Though the current existed passivation techniques are effective, expensive equipments are required. In this paper, a comprehensive understanding of the SiO passivation layer grown by liquid phase deposition (LPD) was presented, which was cost-effective and very simple. It was found that the post-annealing process could significantly enhance the passivation effect of the LPD SiO film. Besides, it was revealed that both chemical passivation and field-effect passivation mechanisms played important roles in outstanding passivation effect of the LPD SiO film through analyzing the minority carrier lifetime and the surface recombination velocity of n-type and p-type silicon wafers. Although the deposition parameters had little influence on the passivation effect, they affected the deposition rate. Therefore, appropriate deposition parameters should be carefully chosen based on the compromise of the deposition rate and fabrication cost. By utilizing the LPD SiO film as surface passivation layer, a 19.5%-efficient silicon solar cell on a large-scale wafer (156 mm × 156 mm) was fabricated.

Keywords： Si solar cell     passivation     SiO2     liquid phase deposition     carrier lifetime    

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Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 398-400 doi: 10.1007/s11684-007-0077-4

Abstract: The aim of this paper was to investigate the relationship between the expression of adrenomedullin (ADM) and microvessel density (MVD) and prognosis in smooth muscle tumor of uterus. The expression of ADM was detected using immunohistochemical staining in specimens from 15 normal controls, 28 cases of uterine leiomyoma (LE) and 19 cases of uterine leiomyosarcoma (LES). The MVD was assayed by immunostainting with CD. There was a positive correlation between the ADM expression and MVD in LE and LES respectively ( = 0.823, <0.01; = 0.793, <0.01). The expression of ADM in LE was statistically lower than that in LES (<0.05). There was a positive correlation between the ADM expression and mitotic figures in LES (<0.05): the more mitotic figures, the higher levels of the ADM expression and poor prognosis. The ADM is an important angiogenic factor in smooth muscle tumor of uterus. The ADM can be used as an accessory marker in estimating the malignant potency of LE and judging the pro gnosis of LES, and as a novel molecular target of anti-angiogenic and anticarcinogenic strategies.

Keywords： anticarcinogenic     microvessel density     malignant potency     muscle     uterine leiomyosarcoma    

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Title Author Date Type Operation

Tanshinone IIA Suppresses Non-Small Cell Lung Cancer Through Beclin-1-Mediated Autophagic Apoptosis

Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang

Journal Article

Building information modeling based on intelligent parametric technology

ZENG Xudong, TAN Jie

Journal Article

Immunoregulatory effects of

Dan Luo, Zhengyun Zuo, Hongyan Zhao, Yong Tan, Cheng Xiao

Journal Article

Introduction to the special section on the Symposium on Computational Fluid Dynamics and Molecular Simulation

Tianwei TAN, Peiyong QIN,

Journal Article

Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng

Journal Article

Nanofiltration for separation and purification of saccharides from biomass

Xianhui Li, Sheng Tan, Jianquan Luo, Manuel Pinelo

Journal Article

Creative design inspired by biological knowledge: Technologies and methods

Runhua TAN, Wei LIU, Guozhong CAO, Yuan SHI

Journal Article

Dilution rate and microstructure of TIG arc Ni-Al powder surfacing layer

SHAN Jiguo, DONG Wei, TAN Wenda, ZHANG Di, REN Jialie

Journal Article

Shape design of arch dams under load uncertainties with robust optimization

Fengjie TAN, Tom LAHMER

Journal Article

Study on the cohesion and adhesion of hot-poured crack sealants

Meng GUO, Yiqiu TAN, Xuesong DU, Zhaofeng LV

Journal Article

Fabrication of titanosilicate pillared MFI zeolites with tailored catalytic activity

Baoyu Liu, Qiaowen Mu, Jiajin Huang, Wei Tan, Jing Xiao

Journal Article

Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Journal Article

A state-of-the-art review on interfacial behavior between asphalt binder and mineral aggregate

Meng GUO, Yiqiu TAN, Linbing WANG, Yue HOU

Journal Article

SiO2 passivation layer grown by liquid phase deposition for silicon solar cell application

Yanlin CHEN,Sihua ZHONG,Miao TAN,Wenzhong SHEN

Journal Article

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor of uterus

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

Journal Article